Mapping genetically compensatory pathways from synthetic lethal interactions in yeast.

ABSTRACT:

Background

Synthetic lethal genetic interaction analysis has been successfully applied to predicting the functions of genes and their pathway identities. In the context of synthetic lethal interaction data alone, the global similarity of synthetic lethal interaction patterns between two genes is used to predict gene function. With physical interaction data, such as protein-protein interactions, the enrichment of physical interactions within subsets of genes and the enrichment of synthetic lethal interactions between those subsets of genes are used as an indication of compensatory pathways.

Result

In this paper, we propose a method of mapping genetically compensatory pathways from synthetic lethal interactions. Our method is designed to discover pairs of gene-sets in which sy

SUBMITTER: Ma X 

PROVIDER: S-EPMC2275788 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature