Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study.

ABSTRACT:

Background

Serum uric acid (UA) levels have recently been shown to be genetically influenced by common polymorphisms in the GLUT9 gene in two genome-wide association analyses of Italian and British populations. Elevated serum UA levels are often found in conjunction with the metabolic syndrome. Hyperuricemia is the major risk factor for gout and has been associated with increased cardiovascular morbidity and mortality. The aim of the present study was to further elucidate the association of polymorphisms in GLUT9 with gout and coronary artery disease (CAD) or myocardial infarction (MI). To test our hypotheses, we performed two large case-control association analyses of individuals from the German MI Family Study.

Methods and findings

First, 665 patients with gout and 665 hea

SUBMITTER: Stark K 

PROVIDER: S-EPMC2275796 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature