Predicted transcription factor binding sites as predictors of operons in Escherichia coli and Streptomyces coelicolor.

ABSTRACT:

Background

As a polycistronic transcriptional unit of one or more adjacent genes, operons play a key role in regulation and function in prokaryotic biology, and a better understanding of how they are constituted and controlled is needed. Recent efforts have attempted to predict operonic status in sequenced genomes using a variety of techniques and data sources. To date, non-homology based operon prediction strategies have mainly used predicted promoters and terminators present at the extremities of transcriptional unit as predictors, with reasonable success. However, transcription factor binding sites (TFBSs), typically found upstream of the first gene in an operon, have not yet been evaluated.

Results

Here we apply a method originally developed for the prediction of TFBSs i

SUBMITTER: Laing E 

PROVIDER: S-EPMC2276206 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature