Analysis of gene expression in normal and cancer cells exposed to gamma-radiation.

ABSTRACT: The expression of many genes is modulated after exposure to ionizing radiation. Identification of specific genes may allow the determination of pathways important in radiation responses. We previously identified modulation of the expression of several genes in response to ionizing radiation treatment. In the present study, we monitored the expression of RGS1, CC3, THBS1, vWF, MADH7, and a novel gene encoding a secreted protein in irradiated Jurkat, TK6, HeLa, and HFL1 cells. The RGS1 is involved in G-protein signaling pathway, CC3 belongs to the complement system, THBS1 is a component of the extracellular matrix, vWF takes part in blood coagulation, and MADH7 is a member of the TGF-beta signal transduction pathway. Our objective was to find similarities and differences in the expression of

SUBMITTER: Chaudhry MA 

PROVIDER: S-EPMC2276817 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature