Derivation of lung epithelium from human cord blood-derived mesenchymal stem cells.

ABSTRACT:

Rationale

Recent studies have suggested that both embryonic stem cells and adult bone marrow stem cells can participate in the regeneration and repair of diseased adult organs, including the lungs. However, the extent of airway epithelial remodeling with adult marrow stem cells is low, and there are no available in vivo data with embryonic stem cells. Human umbilical cord blood contains both hematopoietic and nonhematopoietic stem cells, which have been used clinically as an alternative to bone marrow transplantation for hematologic malignancies and other diseases.

Objectives

We hypothesized that human umbilical cord blood stem cells might be an effective alternative to adult bone marrow and embryonic stem cells for regeneration and repair of injured airway epithelium.

Me

SUBMITTER: Sueblinvong V 

PROVIDER: S-EPMC2277209 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature