Clustering of cognate proteins among distinct proteomes derived from multiple links to a single seed sequence.

ABSTRACT:

Background

Modern proteomes evolved by modification of pre-existing ones. It is extremely important to comparative biology that related proteins be identified as members of the same cognate group, since a characterized putative homolog could be used to find clues about the function of uncharacterized proteins from the same group. Typically, databases of related proteins focus on those from completely-sequenced genomes. Unfortunately, relatively few organisms have had their genomes fully sequenced; accordingly, many proteins are ignored by the currently available databases of cognate proteins, despite the high amount of important genes that are functionally described only for these incomplete proteomes.

Results

We have developed a method to cluster cognate proteins from multi

SUBMITTER: Barbosa-Silva A 

PROVIDER: S-EPMC2277401 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature