Novel genes identified in a high-density genome wide association study for nicotine dependence.

ABSTRACT: Tobacco use is a leading contributor to disability and death worldwide, and genetic factors contribute in part to the development of nicotine dependence. To identify novel genes for which natural variation contributes to the development of nicotine dependence, we performed a comprehensive genome wide association study using nicotine dependent smokers as cases and non-dependent smokers as controls. To allow the efficient, rapid, and cost effective screen of the genome, the study was carried out using a two-stage design. In the first stage, genotyping of over 2.4 million single nucleotide polymorphisms (SNPs) was completed in case and control pools. In the second stage, we selected SNPs for individual genotyping based on the most significant allele frequency differences between cases and con

SUBMITTER: Bierut LJ 

PROVIDER: S-EPMC2278047 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature