A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts.

ABSTRACT: Signaling by Hedgehog (Hh) proteins shapes most tissues and organs in both vertebrates and invertebrates, and its misregulation has been implicated in many human diseases. Although components of the signaling pathway have been identified, key aspects of the signaling mechanism and downstream targets remain to be elucidated. We performed an enhancer/suppressor screen in Drosophila to identify novel components of the pathway and identified 26 autosomal regions that modify a phenotypic readout of Hh signaling. Three of the regions include genes that contribute constituents to the pathway-patched, engrailed, and hh. One of the other regions includes the gene microtubule star (mts) that encodes a subunit of protein phosphatase 2A. We show that mts is necessary for full activation of Hh signalin

SUBMITTER: Casso DJ 

PROVIDER: S-EPMC2278107 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature