Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound.

ABSTRACT: Structural analogues of JS-K, an anti-cancer lead compound, were prepared and their in vitro anti-leukemic activity was determined. The rate of nitric oxide release from the corresponding diazeniumdiolate anions did not appear to affect the anti-leukemic activity of the prodrug forms. Two compounds with potent inhibitory activity and a potentially favorable toxicological profile were identified.

SUBMITTER: Chakrapani H 

PROVIDER: S-EPMC2278236 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature