Pioglitazone administration alters ovarian gene expression in aging obese lethal yellow mice.

ABSTRACT:

Background

Women with polycystic ovary syndrome (PCOS) are often treated with insulin-sensitizing agents, e.g. thiazolidinediones (TZD), which have been shown to reduce androgen levels and improved ovulatory function. Acting via peroxisome proliferator-activated receptor (PPAR) gamma, TZD alter the expression of a large variety of genes. Lethal yellow (LY; C57BL/6J Ay/a) mice, possessing a mutation (Ay) in the agouti gene locus, exhibit progressive obesity, reproductive dysfunction, and altered metabolic regulation similar to women with PCOS. The current study was designed to test the hypothesis that prolonged treatment of aging LY mice with the TZD, pioglitazone, alters the ovarian expression of genes that may impact reproduction.

Methods

Female LY mice received daily oral

SUBMITTER: Brannian JD 

PROVIDER: S-EPMC2279121 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature