Links between core promoter and basic gene features influence gene expression.

ABSTRACT:

Background

Diversity in rates of gene expression is essential for basic cell functions and is controlled by a variety of intricate mechanisms. Revealing general mechanisms that control gene expression is important for understanding normal and pathological cell functions and for improving the design of expression systems. Here we analyzed the relationship between general features of genes and their contribution to expression levels.

Results

Genes were divided into four groups according to their core promoter type and their characteristics analyzed statistically. Surprisingly we found that small variations in the TATA box are linked to large differences in gene length. Genes containing canonical TATA are generally short whereas long genes are associated with either non-canonic

SUBMITTER: Moshonov S 

PROVIDER: S-EPMC2279122 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature