Database searching by flexible protein structure alignment.

ABSTRACT: We have recently developed a flexible protein structure alignment program (FATCAT) that identifies structural similarity, at the same time accounting for flexibility of protein structures. One of the most important applications of a structure alignment method is to aid in functional annotations by identifying similar structures in large structural databases. However, none of the flexible structure alignment methods were applied in this task because of a lack of significance estimation of flexible alignments. In this paper, we developed an estimate of the statistical significance of FATCAT alignment score, allowing us to use it as a database-searching tool. The results reported here show that (1) the distribution of the similarity score of FATCAT alignment between two unrelated protein stru

SUBMITTER: Ye Y 

PROVIDER: S-EPMC2279924 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature