Linkage disequilibrium mapping in isolated populations: the example of Finland revisited.

ABSTRACT: Linkage disequilibrium analysis can provide high resolution in the mapping of disease genes because it incorporates information on recombinations that have occurred during the entire period from the mutational event to the present. A circumstance particularly favorable for high-resolution mapping is when a single founding mutation segregates in an isolated population. We review here the population structure of Finland in which a small founder population some 100 generations ago has expanded into 5.1 million people today. Among the 30-odd autosomal recessive disorders that are more prevalent in Finland than elsewhere, several appear to have segregated for this entire period in the "panmictic" southern Finnish population. Linkage disequilibrium analysis has allowed precise mapping and determ

SUBMITTER: de la Chapelle A 

PROVIDER: S-EPMC22846 | biostudies-literature | 1998 Oct

REPOSITORIES: biostudies-literature