Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces.

ABSTRACT: The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted. Each protein contains an uninterrupted array of from four to 30 examples of the very widely occurring complement control protein (CCP, or sushi) module. The CCP modules mediate specific protein-protein and protein-carbohydrate interactions that are key to the biological function of the RCA and, paradoxically, provide binding sites for numerous pathogens. Although structural and mutagenesis studies of CCP modules have addressed some aspects of molecular recognition, there have been no studies of the role of molecular dynamics in the interaction of CCP modules with their binding partners. NMR ha

SUBMITTER: O'Leary JM 

PROVIDER: S-EPMC2286753 | biostudies-literature | 2004 May

REPOSITORIES: biostudies-literature