Target-dependent inhibition of sympathetic neuron growth via modulation of a BMP signaling pathway.

ABSTRACT: Target-derived factors modulate many aspects of peripheral neuron development including neuronal growth, survival, and maturation. Less is known about how initial target contact regulates changes in gene expression associated with these developmental processes. One early consequence of contact between growing sympathetic neurons and their cardiac myocyte targets is the inhibition of neuronal outgrowth. Analysis of neuronal gene expression following this contact revealed coordinate regulation of a bone morphogenetic protein (BMP)-dependent growth pathway in which basic helix-loop-helix transcription factors and downstream neurofilament expression contribute to the growth dynamics of developing sympathetic neurons. BMP2 had dose-dependent growth-promoting effects on sympathetic neurons cultu

SUBMITTER: Moon JI 

PROVIDER: S-EPMC2287379 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature