Proteomics computational analyses suggest that baculovirus GP64 superfamily proteins are class III penetrenes.

ABSTRACT:

Background

Members of the Baculoviridae encode two types of proteins that mediate virus:cell membrane fusion and penetration into the host cell. Alignments of primary amino acid sequences indicate that baculovirus fusion proteins of group I nucleopolyhedroviruses (NPV) form the GP64 superfamily. The structure of these viral penetrenes has not been determined. The GP64 superfamily includes the glycoprotein (GP) encoded by members of the Thogotovirus genus of the Orthomyxoviridae. The entry proteins of other baculoviruses, group II NPV and granuloviruses, are class I penetrenes.

Results

Class III penetrenes encoded by members of the Rhabdoviridae and Herpesviridae have an internal fusion domain comprised of beta sheets, other beta sheet domains, an extended alpha helical domai

SUBMITTER: Garry CE 

PROVIDER: S-EPMC2288602 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature