Neural responses to monetary incentives in major depression.

ABSTRACT:

Background

Reduced responsiveness to positive incentives is a central feature of Major Depressive Disorder (MDD). In the present study, we compared neural correlates of monetary incentive processing in unmedicated depressed participants and never-depressed control subjects.

Methods

Fourteen currently depressed and 12 never-depressed participants underwent functional magnetic resonance imaging while participating in a monetary incentive delay task. During the task, participants were cued to anticipate and respond to a rapidly presented target to gain or avoid losing varying amounts of money.

Results

Depressed and never-depressed participants did not differ in nucleus accumbens (NAcc) activation or in affective or behavioral responses during gain anticipation. Depressed

SUBMITTER: Knutson B 

PROVIDER: S-EPMC2290738 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature