Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr.

ABSTRACT: The rifamycin antibiotic rifampin is important for the treatment of tuberculosis and infections caused by multidrug-resistant Staphylococcus aureus. Recent iterations of the rifampin core structure have resulted in new drugs and drug candidates for the treatment of a much broader range of infectious diseases. This expanded use of rifamycin antibiotics has the potential to select for increased resistance. One poorly characterized mechanism of resistance is through Arr enzymes that catalyze ADP-ribosylation of rifamycins. We find that genes encoding predicted Arr enzymes are widely distributed in the genomes of pathogenic and nonpathogenic bacteria. Biochemical analysis of three representative Arr enzymes from environmental and pathogenic bacterial sources shows that these have equally effic

SUBMITTER: Baysarowich J 

PROVIDER: S-EPMC2290778 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature