Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors.

ABSTRACT: Intracellular transport is based on molecular motors that pull cargos along cytoskeletal filaments. One motor species always moves in one direction, e.g., conventional kinesin moves to the microtubule plus end, whereas cytoplasmic dynein moves to the microtubule minus end. However, many cellular cargoes are observed to move bidirectionally, involving both plus- and minus-end-directed motors. The presumably simplest mechanism for such bidirectional transport is provided by a tug-of-war between the two motor species. This mechanism is studied theoretically using the load-dependent transport properties of individual motors as measured in single-molecule experiments. In contrast to previous expectations, such a tug-of-war is found to be highly cooperative and to exhibit seven different motilit

SUBMITTER: Muller MJ 

PROVIDER: S-EPMC2290779 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature