Myosin V and Kinesin act as tethers to enhance each others' processivity.

ABSTRACT: Organelle transport to the periphery of the cell involves coordinated transport between the processive motors kinesin and myosin V. Long-range transport takes place on microtubule tracks, whereas final delivery involves shorter actin-based movements. The concept that motors only function on their appropriate track required further investigation with the recent observation that myosin V undergoes a diffusional search on microtubules. Here we show, using single-molecule techniques, that a functional consequence of myosin V's diffusion on microtubules is a significant enhancement of the processive run length of kinesin when both motors are present on the same cargo. The degree of run length enhancement correlated with the net positive charge in loop 2 of myosin V. On actin, myosin V also unde

SUBMITTER: Ali MY 

PROVIDER: S-EPMC2290781 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature