Population genomics of the wild yeast Saccharomyces paradoxus: Quantifying the life cycle.

ABSTRACT: Most microbes have complex life cycles with multiple modes of reproduction that differ in their effects on DNA sequence variation. Population genomic analyses can therefore be used to estimate the relative frequencies of these different modes in nature. The life cycle of the wild yeast Saccharomyces paradoxus is complex, including clonal reproduction, outcrossing, and two different modes of inbreeding. To quantify these different aspects we analyzed DNA sequence variation in the third chromosome among 20 isolates from two populations. Measures of mutational and recombinational diversity were used to make two independent estimates of the population size. In an obligately sexual population these values should be approximately equal. Instead there is a discrepancy of about three orders of mag

SUBMITTER: Tsai IJ 

PROVIDER: S-EPMC2290798 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature