Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals.

ABSTRACT:

Background

The draft mouse (Mus musculus) genome sequence revealed an unexpected proliferation of gene duplicates encoding a family of secretoglobin proteins including the androgen-binding protein (ABP) alpha, beta and gamma subunits. Further investigation of 14 alpha-like (Abpa) and 13 beta- or gamma-like (Abpbg) undisrupted gene sequences revealed a rich diversity of developmental stage-, sex- and tissue-specific expression. Despite these studies, our understanding of the evolution of this gene family remains incomplete. Questions arise from imperfections in the initial mouse genome assembly and a dearth of information about the gene family structure in other rodents and mammals.

Results

Here, we interrogate the latest 'finished' mouse (Mus musculus) genome sequence assemb

SUBMITTER: Laukaitis CM 

PROVIDER: S-EPMC2291036 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature