Influence of APOE genotypes and VKORC1 haplotypes on warfarin dose requirements in Asian patients.

ABSTRACT:

What is already known about this subject

Recent studies on pharmacogenetics of warfarin have implicated apolipoprotein E (APOE) polymorphisms to influence the vitamin K dependent coagulation cascade and hence the efficacy of warfarin. Studies among Caucasian and African Americans showed a significant but conflicting role of apolipoprotein E (APOE) isoforms in warfarin pharmacogenetics. The contribution of APOE isoforms in influencing variations in warfarin requirements in Asian subjects remains to be investigated.

What this study adds

This is the first report of a population study in Asians exploring the role of isoforms encoded by three APOE alleles (epsilon 2, epsilon 3, epsilon 4) in influencing warfarin dose requirements. The present study showed that the APOE epsilon 3/

SUBMITTER: Lal S 

PROVIDER: S-EPMC2291220 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature