Sep7 is essential to modify septin ring dynamics and inhibit cell separation during Candida albicans hyphal growth.

ABSTRACT: When Candida albicans yeast cells receive the appropriate stimulus, they switch to hyphal growth, characterized by continuous apical elongation and the inhibition of cell separation. The molecular basis of this inhibition is poorly known, despite its crucial importance for hyphal development. In C. albicans, septins are important for hypha formation and virulence. Here, we used fluorescence recovery after photobleaching analysis to characterize the dynamics of septin rings during yeast and hyphal growth. On hyphal induction, septin rings are converted to a hyphal-specific state, characterized by the presence of a frozen core formed by Sep7/Shs1, Cdc3 and Cdc12, whereas Cdc10 is highly dynamic and oscillates between the ring and the cytoplasm. Conversion of septin rings to the hyphal-specif

SUBMITTER: Gonzalez-Novo A 

PROVIDER: S-EPMC2291409 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature