Effect of vitamin K supplementation on bone loss in elderly men and women.

ABSTRACT:

Context

Vitamin K has been implicated in bone health, primarily in observational studies. However, little is known about the role of phylloquinone supplementation on prevention of bone loss in men and women.

Objective

The objective of this study was to determine the effect of 3-yr phylloquinone supplementation on change in bone mineral density (BMD) of the femoral neck bone in older men and women who were calcium and vitamin D replete.

Design, participants, and intervention

In this 3-yr, double-blind, controlled trial, 452 men and women (60-80 yr) were randomized equally to receive a multivitamin that contained either 500 mug/d or no phylloquinone plus a daily calcium (600 mg elemental calcium) and vitamin D (400 IU) supplement.

Main outcome measures

Measuremen

SUBMITTER: Booth SL 

PROVIDER: S-EPMC2291488 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature