Inferring microRNA activities by combining gene expression with microRNA target prediction.

ABSTRACT:

Background

MicroRNAs (miRNAs) play crucial roles in a variety of biological processes via regulating expression of their target genes at the mRNA level. A number of computational approaches regarding miRNAs have been proposed, but most of them focus on miRNA gene finding or target predictions. Little computational work has been done to investigate the effective regulation of miRNAs.

Methodology/principal findings

We propose a method to infer the effective regulatory activities of miRNAs by integrating microarray expression data with miRNA target predictions. The method is based on the idea that regulatory activity changes of miRNAs could be reflected by the expression changes of their target transcripts measured by microarray. To validate this method, we apply it to the micr

SUBMITTER: Cheng C 

PROVIDER: S-EPMC2291556 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature