Ontology highlight
ABSTRACT:
SUBMITTER: Forbes EE
PROVIDER: S-EPMC2292227 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20080331 4
Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation and induction of the effector phase of food allergy. However, the mechanism by which sensitization and mast cell responses occurs is largely unknown. We demonstrate that interleukin (IL)-9 has an important role in this process. IL-9-deficient mice fail to develop experimental oral antigen-induced intestinal anaphylaxis, and intestinal IL-9 overexpression induces an intestinal anaphylaxis phenotype (intesti ...[more]