Effect of high throughput RHD typing of fetal DNA in maternal plasma on use of anti-RhD immunoglobulin in RhD negative pregnant women: prospective feasibility study.

ABSTRACT:

Objectives

To assess the feasibility of applying a high throughput method, with an automated robotic technique, for predicting fetal RhD phenotype from fetal DNA in the plasma of RhD negative pregnant women to avoid unnecessary treatment with anti-RhD immunoglobulin.

Design

Prospective comparison of fetal RHD genotype determined from fetal DNA in maternal plasma with the serologically determined fetal RhD phenotype from cord blood.

Setting

Antenatal clinics and antenatal testing laboratories in the Midlands and north of England and an international blood group reference laboratory.

Participants

Pregnant women of known gestation identified as RhD negative by an antenatal testing laboratory. Samples from 1997 women were taken at or before the 28 week antenatal vi

SUBMITTER: Finning K 

PROVIDER: S-EPMC2292334 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature