Arsenic-induced changes in the gene expression of lung epithelial L2 cells: implications in carcinogenesis.

ABSTRACT:

Background

Arsenic is a carcinogen that is known to induce cell transformation and tumor formation. Although studies have been performed to examine the modulation of signaling molecules caused by arsenic exposure, the molecular mechanisms by which arsenic causes cancer are still unclear. We hypothesized that arsenic alters gene expression leading to carcinogenesis in the lung.

Results

In this study, we examined global gene expression in response to 0.75 microM arsenic treatment for 1-7 days in a rat lung epithelial cell line (L2) using an in-house 10 k rat DNA microarray. One hundred thirty one genes were identified using the one-class statistical analysis of microarray (SAM) test. Of them, 33 genes had a fold change of > or = 2 between at least two time points. These genes

SUBMITTER: Posey T 

PROVIDER: S-EPMC2292705 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature