Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans.

ABSTRACT:

Rationale

The basis for gender influences on allergen-specific IgEs is unclear.

Objectives

To perform regular and sex-stratified genomewide linkage analyses of IgE to each of three allergens (Ascaris lumbricoides, Blatella germanica [German cockroach]), and Dermatophagoides pteronyssinus [dust mite]) and to conduct an association study of a candidate gene in a linked genomic region.

Methods

Genomewide linkage analyses of allergen-specific IgEs were conducted in 653 members of eight large families of Costa Rican children with asthma. An analysis of the association between single-nucleotide polymorphisms in thymic stromal lymphopoietin (TSLP) and IgE measurements was conducted in 417 parent-child trios in Costa Rica. Significant results were replicated in 470 families o

SUBMITTER: Hunninghake GM 

PROVIDER: S-EPMC2292826 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature