Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific.

ABSTRACT: Naturally acquired antibody responses provide partial protection from clinical malaria, and blood-stage parasite vaccines under development aim to prime such responses. To investigate the determinants of antibody response longevity, immunoglobulin G (IgG) antibodies to several blood-stage vaccine candidate antigens in the sera of two cohorts of children of up to 6 years of age during the dry seasons of 2003 and 2004 in The Gambia were examined. The first cohort showed that most antibodies were lost within less than 4 months of the first sampling if a persistent infection was not present, so the study of the second-year cohort involved collecting samples from individuals every 2 weeks over a 3-month period. Antibody responses in the second cohort were also influenced by persistent malaria i

SUBMITTER: Akpogheneta OJ 

PROVIDER: S-EPMC2292892 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature