Potent human immunodeficiency virus-neutralizing and complement lysis activities of antibodies are not obligatorily linked.

ABSTRACT: To evaluate the contribution of complement-mediated lysis to the in vivo activities of neutralizing antibodies, we analyzed the influence of complement activation on treatment success in a recent passive immunization trial with the neutralizing monoclonal antibodies 2G12, 2F5, and 4E10. Administration of monoclonal antibodies led to an immediate, high activation of the complement system even in the absence of viremia in the 14 participating human immunodeficiency virus-infected individuals. Lysis activity measured in patient plasma increased during passive immunization; however, the increases were modest and only partially attributable to the administration of antibodies. We found that unlike neutralization activity, lysis activity was not associated with treatment success in this trial. C

SUBMITTER: Huber M 

PROVIDER: S-EPMC2293011 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature