Genome-scale metabolic network analysis of the opportunistic pathogen Pseudomonas aeruginosa PAO1.

ABSTRACT: Pseudomonas aeruginosa is a major life-threatening opportunistic pathogen that commonly infects immunocompromised patients. This bacterium owes its success as a pathogen largely to its metabolic versatility and flexibility. A thorough understanding of P. aeruginosa's metabolism is thus pivotal for the design of effective intervention strategies. Here we aim to provide, through systems analysis, a basis for the characterization of the genome-scale properties of this pathogen's versatile metabolic network. To this end, we reconstructed a genome-scale metabolic network of Pseudomonas aeruginosa PAO1. This reconstruction accounts for 1,056 genes (19% of the genome), 1,030 proteins, and 883 reactions. Flux balance analysis was used to identify key features of P. aeruginosa metabolism, such as g

SUBMITTER: Oberhardt MA 

PROVIDER: S-EPMC2293256 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature