Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.

ABSTRACT: The expression of unconventional vesicular glutamate transporter VGLUT3 by neurons known to release a different classical transmitter has suggested novel roles for signaling by glutamate, but this distribution has raised questions about whether the protein actually contributes to glutamate release. We now report that mice lacking VGLUT3 are profoundly deaf due to the absence of glutamate release from hair cells at the first synapse in the auditory pathway. The early degeneration of some cochlear ganglion neurons in knockout mice also indicates an important developmental role for the glutamate released by hair cells before the onset of hearing. In addition, the mice exhibit primary, generalized epilepsy that is accompanied by remarkably little change in ongoing motor behavior. The glutamate

SUBMITTER: Seal RP 

PROVIDER: S-EPMC2293283 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature