The pyrroloquinoline quinone biosynthesis pathway revisited: a structural approach.

ABSTRACT:

Background

The biosynthesis pathway of Pyrroloquinoline quinone, a bacterial redox active cofactor for numerous alcohol and aldose dehydrogenases, is largely unknown, but it is proven that at least six genes in Klebsiella pneumoniae (PqqA-F) are required, all of which are located in the PQQ-operon.

Results

New structural data of some PQQ biosynthesis proteins and their homologues provide new insights and functional assignments of the proteins in the pathway. Based on sequence analysis and homology models we propose the role and catalytic function for each enzyme involved in this intriguing biosynthesis pathway.

Conclusion

PQQ is derived from the two amino acids glutamate and tyrosine encoded in the precursor peptide PqqA. Five reactions are necessary to form this quin

SUBMITTER: Puehringer S 

PROVIDER: S-EPMC2294125 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature