Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes.

ABSTRACT:

Background

Prion infection results in progressive neurodegeneration of the central nervous system invariably resulting in death. The pathological effects of prion diseases in the brain are morphologically well defined, such as gliosis, vacuolation, and the accumulation of disease-specific protease-resistant prion protein (PrPSc). However, the underlying molecular events that lead to the death of neurons are poorly characterised.

Results

In this study cDNA microarrays were used to profile gene expression changes in the brains of two different strains of mice infected with three strains of mouse-adapted scrapie. Extensive data was collected and analyzed, from which we identified a core group of 349 prion-related genes (PRGs) that consistently showed altered expression in mouse

SUBMITTER: Sorensen G 

PROVIDER: S-EPMC2294129 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature