RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2.

ABSTRACT: Steroids, thyroid hormones, vitamin D3, and retinoids are lipophilic small molecules that regulate diverse biological effects such as cell differentiation, development, and homeostasis. The actions of these hormones are mediated by steroid/nuclear receptors which function as ligand-dependent transcriptional regulators. Transcriptional activation by ligand-bound receptors is a complex process requiring dissociation and recruitment of several additional cofactors. We report here the cloning and characterization of receptor-associated coactivator 3 (RAC3), a human transcriptional coactivator for steroid/nuclear receptors. RAC3 interacts with several liganded receptors through a mechanism which requires their respective ligand-dependent activation domains. RAC3 can activate transcription when

SUBMITTER: Li H 

PROVIDER: S-EPMC22964 | biostudies-literature | 1997 Aug

REPOSITORIES: biostudies-literature