Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures.

ABSTRACT: Many complex neuronal circuits have been shown to display nonrandom features in their connectivity. However, the functional impact of nonrandom network topologies in neurological diseases is not well understood. The dentate gyrus is an excellent circuit in which to study such functional implications because proepileptic insults cause its structure to undergo a number of specific changes in both humans and animals, including the formation of previously nonexistent granule cell-to-granule cell recurrent excitatory connections. Here, we use a large-scale, biophysically realistic model of the epileptic rat dentate gyrus to reconnect the aberrant recurrent granule cell network in four biologically plausible ways to determine how nonrandom connectivity promotes hyperexcitability after injury. We

SUBMITTER: Morgan RJ 

PROVIDER: S-EPMC2299224 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature