P16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer.

ABSTRACT: Low gene expression of folylpolyglutamate synthase (FPGS) in colorectal mucosa correlates with low folate levels and poor survival of colorectal cancer (CRC) patients. Because gene-specific hypermethylation is affected by the folate level, the hypermethylation status in mucosa may also be linked to clinical outcome of CRC patients. The tumor suppressor gene p16INK4a (p16) regulates the cell cycle and angiogenic switch. In human neoplastic tissues, the main mechanism of p16 inactivation is promoter methylation. The aim of the study was to determine whether hypermethylation of the p16 promoter could be detected in mucosa of CRC patients (n = 181) and to analyze if hypermethylation was related to survival. The relation between p16 hypermethylation and expression of FPGS and two other folate-a

SUBMITTER: Wettergren Y 

PROVIDER: S-EPMC2309648 | biostudies-literature | 2008 Jul-Aug

REPOSITORIES: biostudies-literature