Developmental patterning of glutamatergic synapses onto retinal ganglion cells.

ABSTRACT:

Background

Neurons receive excitatory synaptic inputs that are distributed across their dendritic arbors at densities and with spatial patterns that influence their output. How specific synaptic distributions are attained during development is not well understood. The distribution of glutamatergic inputs across the dendritic arbors of mammalian retinal ganglion cells (RGCs) has long been correlated to the spatial receptive field profiles of these neurons. Thus, determining how glutamatergic inputs are patterned onto RGC dendritic arbors during development could provide insight into the cellular mechanisms that shape their functional receptive fields.

Results

We transfected developing and mature mouse RGCs with plasmids encoding fluorescent proteins that label their dendrites

SUBMITTER: Morgan JL 

PROVIDER: S-EPMC2311295 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature