Severe anaemia is not associated with HIV-1 env gene characteristics in Malawian children.

ABSTRACT:

Background

Anaemia is the most common haematological complication of HIV and associated with a high morbidity and a poor prognosis. The pathogenesis of HIV-associated anaemia is poorly understood and may include a direct effect of HIV on erythropoiesis. In vitro studies have suggested that specific HIV strains, like X4 that uses the CXCR4 co-receptor present on erythroid precursors, are associated with diminished erythropoiesis. This co-receptor affinity is determined by changes in the hypervariable loop of the HIV-1 envelope genome. In a previous case-control study we observed an association between HIV and severe anaemia in Malawian children that could not be fully explained by secondary infections and micronutrient deficiencies alone. We therefore explored the possibility that a

SUBMITTER: Calis JC 

PROVIDER: S-EPMC2311312 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature