Parallel striatal and hippocampal systems for landmarks and boundaries in spatial memory.

ABSTRACT: How the memory systems centered on the hippocampus and dorsal striatum interact to support behavior remains controversial. We used functional MRI while people learned the locations of objects by collecting and replacing them over multiple trials within a virtual environment comprising a landmark, a circular boundary, and distant cues for orientation. The relative location of landmark and boundary was occasionally changed, with specific objects paired with one or other cue, allowing dissociation of learning and performance relative to either cue. Right posterior hippocampal activation reflected learning and remembering of boundary-related locations, whereas right dorsal striatal activation reflected learning and remembering of landmark-related locations. Within the right hippocampus, anteri

SUBMITTER: Doeller CF 

PROVIDER: S-EPMC2311337 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature