An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins.

ABSTRACT: Two-component signal transduction systems with membrane-embedded sensor histidine kinases are believed to recognize environmental signals and transduce this information over the cellular membrane to influence the activity of a transcription factor to which they are mated. The YycG sensor kinase of Bacillus subtilis, containing two transmembrane helices, is subject to a complicated activity-control circuit involving two other proteins with N-terminal transmembrane helices, YycH and YycI. Truncation studies of YycH and YycI demonstrated that the individual transmembrane helices of these proteins are sufficient to adjust YycG activity, indicating that this control is achieved at the membrane level. A replica exchange molecular dynamics computational approach generated in silico structural mod

SUBMITTER: Szurmant H 

PROVIDER: S-EPMC2311355 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature