Coordinated regulation of intestinal functions in C. elegans by LIN-35/Rb and SLR-2.

ABSTRACT: LIN-35 is the sole C. elegans representative of the pocket protein family, which includes the mammalian Retinoblastoma protein pRb and its paralogs p107 and p130. In addition to having a well-established and central role in cell cycle regulation, pocket proteins have been increasingly implicated in the control of critical and diverse developmental and cellular processes. To gain a greater understanding of the roles of pocket proteins during development, we have characterized a synthetic genetic interaction between lin-35 and slr-2, which we show encodes a C2H2-type Zn-finger protein. Whereas animals harboring single mutations in lin-35 or slr-2 are viable and fertile, lin-35; slr-2 double mutants arrest uniformly in early larval development without obvious morphological defects. Using a co

SUBMITTER: Kirienko NV 

PROVIDER: S-EPMC2312330 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature