The phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions.

ABSTRACT:

Background

The mammalian heme peroxidases (MHPs) are a medically important group of enzymes. Included in this group are myeloperoxidase, eosinophil peroxidase, lactoperoxidase, and thyroid peroxidase. These enzymes are associated with such diverse diseases as asthma, Alzheimer's disease and inflammatory vascular disease. Despite much effort to elucidate a clearer understanding of the function of the 4 major groups of this multigene family, we still do not have a clear understanding of their relationships to each other.

Results

Sufficient signal exists for the resolution of the evolutionary relationships of this family of enzymes. We demonstrate, using a root mean squared deviation statistic, how the removal of the fastest evolving sites aids in the minimisation of the effect

SUBMITTER: Loughran NB 

PROVIDER: S-EPMC2315650 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature