Structural deformation upon protein-protein interaction: a structural alphabet approach.

ABSTRACT:

Background

In a number of protein-protein complexes, the 3D structures of bound and unbound partners significantly differ, supporting the induced fit hypothesis for protein-protein binding.

Results

In this study, we explore the induced fit modifications on a set of 124 proteins available in both bound and unbound forms, in terms of local structure. The local structure is described thanks to a structural alphabet of 27 structural letters that allows a detailed description of the backbone. Using a control set to distinguish induced fit from experimental error and natural protein flexibility, we show that the fraction of structural letters modified upon binding is significantly greater than in the control set (36% versus 28%). This proportion is even greater in the interface re

SUBMITTER: Martin J 

PROVIDER: S-EPMC2315654 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature