Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD.

ABSTRACT:

Background

The lectin-like oxidized LDL receptor LOX-1 (encoded by OLR1) is believed to play a key role in atherogenesis and some reports suggest an association of OLR1 polymorphisms with myocardial infarction (MI). We tested whether single nucleotide polymorphisms (SNPs) in OLR1 are associated with clinically significant CAD in the Atherosclerotic Disease, VAscular FuNction, & Geneti C Epidemiology (ADVANCE) study.

Methods

ADVANCE is a population-based case-control study of subjects receiving care within Kaiser Permanente of Northern California including a subset of participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study. We first resequenced the promoter, exonic, and splice site regions of OLR1 and then genotyped four single nucleotide polymorph

SUBMITTER: Knowles JW 

PROVIDER: S-EPMC2322963 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature