Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype.

ABSTRACT:

Background

Although uterine macrophages are thought to play an important regulatory role at the maternal-fetal interface, their global gene expression profile is not known.

Methodology/principal findings

Using micro-array comprising approximately 14,000 genes, the gene expression pattern of human first trimester decidual CD14+ monocytes/macrophages was characterized and compared with the expression profile of the corresponding cells in blood. Some of the key findings were confirmed by real time PCR or by secreted protein. A unique gene expression pattern intrinsic of first trimester decidual CD14+ cells was demonstrated. A large number of regulated genes were functionally related to immunomodulation and tissue remodelling, corroborating polarization patterns of differentiate

SUBMITTER: Gustafsson C 

PROVIDER: S-EPMC2323105 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature