Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer.

ABSTRACT:

Background

The expression of carcino-embryonic antigen by colorectal cancer is an example of oncogenic activation of embryonic gene expression. Hypothesizing that oncogenesis-recapitulating-ontogenesis may represent a broad programmatic commitment, we compared gene expression patterns of human colorectal cancers (CRCs) and mouse colon tumor models to those of mouse colon development embryonic days 13.5-18.5.

Results

We report here that 39 colon tumors from four independent mouse models and 100 human CRCs encompassing all clinical stages shared a striking recapitulation of embryonic colon gene expression. Compared to normal adult colon, all mouse and human tumors over-expressed a large cluster of genes highly enriched for functional association to the control of cell cycle pr

SUBMITTER: Kaiser S 

PROVIDER: S-EPMC2323222 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature