Global analysis of patterns of gene expression during Drosophila embryogenesis.

ABSTRACT:

Background

Cell and tissue specific gene expression is a defining feature of embryonic development in multi-cellular organisms. However, the range of gene expression patterns, the extent of the correlation of expression with function, and the classes of genes whose spatial expression are tightly regulated have been unclear due to the lack of an unbiased, genome-wide survey of gene expression patterns.

Results

We determined and documented embryonic expression patterns for 6,003 (44%) of the 13,659 protein-coding genes identified in the Drosophila melanogaster genome with over 70,000 images and controlled vocabulary annotations. Individual expression patterns are extraordinarily diverse, but by supplementing qualitative in situ hybridization data with quantitative microarray t

SUBMITTER: Tomancak P 

PROVIDER: S-EPMC2323238 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature